• Journal Article

Dry Powder Nasal Vaccines as an Alternative to Needle-Based Delivery

Citation

Garmise, R. J., & Hickey, A. (2009). Dry Powder Nasal Vaccines as an Alternative to Needle-Based Delivery. Critical Reviews in Therapeutic Drug Carrier Systems, 26(1), 1-27. DOI: 10.1615/CritRevTherDrugCarrierSyst.v26.i1.10

Abstract

Drug delivery to the nasal cavity has been achieved using a variety of systems. Dry powder vaccines offer the advantages of chemical and physical stability in comparison to liquid formulations. An intranasal vaccine can elicit both a local and systemic immune response. Mucoadhesive compounds can extend the residence time for powder formulations on the nasal mucosa, potentially increasing the immune response. Manufacture and characterization of a formulation containing particles of a dry powder vaccine are discussed