• Journal Article

Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN-003 (VOICE) study

Citation

Van Der Straten, A., Brown, E. R., Marrazzo, J. M., Chirenje, M. Z., Liu, K., Gomez, K., ... Hendrix, C. W. (2016). Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN-003 (VOICE) study. Journal of the International AIDS Society, 19(1), e20642. DOI: 10.7448/ias.19.1.20642

Abstract

INTRODUCTION: In the Microbicide Trial Network MTN-003 (VOICE) study, a Phase IIB pre-exposure prophylaxis trial of daily oral or vaginal tenofovir (TFV), product adherence was poor based on pharmacokinetic (PK) drug detection in a random subsample. Here, we sought to compare behavioural and PK measures of adherence and examined correlates of adherence misreporting. METHODS: We included participants with PK and behavioural data from VOICE random subsample. Behavioural assessments included face-to-face interviews (FTFI), audio computer-assisted self-interviewing (ACASI) and pharmacy-returned product counts (PC). TFV concentrations 0.65 for any single or combined behavioural measures. Significant (p