Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective a4B2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders

Y Xiao; A Mazurov; L Miao; B Bhatti; J. Strachan; S Akireddy; S Murthy; D Kombo; P Hammond; J Zhang; T Hauser; K Jordan; C Miller; J Speake; Gregory Gatto; D Yohannes

Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective a4B2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders

Mazurov, A., Miao, L., Bhatti, B., Strachan, J., Akireddy, S., Murthy, S., ... Yohannes, D. (2012). Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective a4B2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. Journal of Medicinal Chemistry, 55(22), 9793 - 9809.

Copy citation

Recent Publications

Article

The evolution of minimally invasive tissue sampling in postmortem examination

Article

Accountability for SRHR in the context of the COVID-19 pandemic

Article

Validation of simple dichotomous self-report on prenatal alcohol and other drug use in women attending midwife obstetric units in the Cape Metropole, South Africa

Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective a4B2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders

Publications Info

Recent Publications

Article

The evolution of minimally invasive tissue sampling in postmortem examination

Article

Accountability for SRHR in the context of the COVID-19 pandemic

Article

Validation of simple dichotomous self-report on prenatal alcohol and other drug use in women attending midwife obstetric units in the Cape Metropole, South Africa

Article

Nicotinic acetylcholine receptor accessory subunits determine the activity profile of epibatidine derivatives