• Journal Article

Deposition of [H-3]cocaine, [H-3]nicotine, and [H-3]flunitrazepam in mouse hair melanosomes after systemic administration

Citation

Stout, P., & Ruth, J. A. (1999). Deposition of [H-3]cocaine, [H-3]nicotine, and [H-3]flunitrazepam in mouse hair melanosomes after systemic administration. Drug Metabolism and Disposition, 27(6), 731-735.

Abstract

Microautoradiography was employed to show that association of drugs from the serum directly with forming hair pigment is a primary pathway of deposition into the hair, After systemic administration of [H-3]flunitrazepam, [H-3]nicotine, and [H-3]cocaine, association of all three drugs with melanin in the forming hair was observed within minutes of dosage. Sebum was determined to be an insignificant deposition route for all three drugs, Pigmented mice had significantly higher concentrations of all three drugs than did nonpigmented mice. The results provide a better basis for ultimately using hair for reliable analysis of drug and environmental toxin exposure