Cytotoxic prenylated xanthones,and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum
Six new xanthones, cratoxyarborenones A?F (1?6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and ?-tocotrienol, were obtained as inactive constituents.
Seo, E-K., Kim, NC., Wani, M., Wall, M., Navarro, H., Burgess, J., ... Kinghorn, AD. (2002). Cytotoxic prenylated xanthones,and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum. Journal of Natural Products, 65(3), 299-305. DOI: 10.1021/np010395f