Cytotoxic prenylated xanthones,and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

Hernan A. Navarro; Jason P. Burgess; Monroe E. Wall; Mansukh C. Wani; Eun-Kyoung Seo; NC Kim; Mansukh C. Wani; Monroe E. Wall; Hernan A. Navarro; Jason P. Burgess; K Kawanishi; LBS Kardono; S Riswan; WC Rose; CR Fairchild; NR Farnsworth; AD Kinghorn

Cytotoxic prenylated xanthones,and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

Seo, E-K., Kim, NC., Wani, M., Wall, M., Navarro, H., Burgess, J., Kawanishi, K., Kardono, LBS., Riswan, S., Rose, WC., Fairchild, CR., Farnsworth, NR., & Kinghorn, AD. (2002). Cytotoxic prenylated xanthones,and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum. Journal of Natural Products, 65(3), 299-305. https://doi.org/10.1021/np010395f

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Abstract

Six new xanthones, cratoxyarborenones A?F (1?6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and ?-tocotrienol, were obtained as inactive constituents.