• Editorial

Corrigendum: Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator AbrB (vol 7, pg 1139, 2000)

Citation

Vaughn, J. L., Feher, A., Naylor, S., Strauch, M. A., & Cavanagh, J. (2005). Corrigendum: Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator AbrB (vol 7, pg 1139, 2000). Nature Structural and Molecular Biology, 12(4), 380-380. DOI: 10.1038/nsmb0405-380

Abstract

Based on a recent bioinformatics analysis, we have refined the dimeric interface of the N-terminal domain of the Bacillus subtilis transition state regulator AbrB. Comprehensive sets of approx300 unambiguous distance constraints (NOEs) and hydrogen exchange data have been collected that now accurately define this interface. There is an additional beta-structure formed between two interlocking subunits of the homodimer. The coordinates of the revised structure and relevant information are now available in the Protein Data Bank (accession code 1Z0R). The original structure described in the manuscript (accession code 1EKT) is now obsolete. The modified AbrB N-terminal domain structure is more consistent with biophysical and mutagenesis data, in particular two DNA-binding mutants, R8S and R15S (unpublished data). The reshaping of the recognition site has these residues appropriately oriented for DNA interactions.