• Patent

Cocaine receptor binding ligands


Kuhar, M. J., Carroll, F., Boja, J. W., Lewin, A., & Abraham, P. (2006). IPC No. U.S.Cocaine receptor binding ligands (Patent No. 7011813.)


Tropane derivatives having a high binding affinity and selectivity for dopamine transporters bear, on the tropane backbone either a carboxylic ester or isoxazole moiety, as well as a substituted phenyl moiety. The compounds have utility both as pharmaceutical and as imaging agents, when one or more atoms are radioactive.