Cocaine receptor binding ligands
Kuhar, MJ., Carroll, F., Boja, JW., Lewin, A., & Abraham, P. (2006). Cocaine receptor binding ligands. (U.S. Patent No. 7011813). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7011813
Abstract
Tropane derivatives having a high binding affinity and selectivity for dopamine transporters bear, on the tropane backbone either a carboxylic ester or isoxazole moiety, as well as a substituted phenyl moiety. The compounds have utility both as pharmaceutical and as imaging agents, when one or more atoms are radioactive.
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