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Bae, M., Mevers, E., Pishchany, G., Whaley, S. G., Rock, C. O., Andes, D. R., Currie, C. R., Pupo, M. T., & Clardy, J. (2021). Chemical exchanges between multilateral symbionts. Organic Letters, 23(5), 1648-1652. https://doi.org/10.1021/acs.orglett.1c00068
Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.