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Camptothecin compounds with a thioether group

Gamcsik, MP., Adams, DJ., Colvin, OM., Wall, M., Wani, M., Manikumar, G., & Pommier, Y. (2004). Camptothecin compounds with a thioether group. (U.S. Patent No. 6825206). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6825206

Abstract

Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex.

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