Camptothecin compounds which are effective anti-tumor compoundsare disclosed. These conjugates inhibit the enzyme topoisomerase Iand enhance the stability of the topoisomerase I-DNA cleavablecomplex.
Camptothecin compounds with a thioether group
Gamcsik, MP., Adams, DJ., Colvin, OM., Wall, M., Wani, M., Manikumar, G., & Pommier, Y. (2004). IPC No. U.S. Camptothecin compounds with a thioether group. (U.S. Patent No. 6825206).