• Patent

Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties

Citation

Wall, M., & Wani, M. (1999). IPC No. U.S.Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties (Patent No. 5932588.)

Abstract

Camptothecin compounds having a --CH.sub.2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.