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Camptothecin compounds with combined topoisomarase I inhibition and DNA alkylation properties

Wall, M., & Wani, M. (1999). Camptothecin compounds with combined topoisomarase I inhibition and DNA alkylation properties. (U.S. Patent No. 5985888). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5985888

Abstract

Camptothecin compounds having a --CH.sub.2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.

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