Camptothecin compounds having a --CH.sub.2 --L group areeffective anti-tumor compounds. These compounds inhibit the enzymetopoisomerase I and DNA of associated topoisomerase I-DNAcomplexes.
Camptothecin compounds with combined topoisomarase I inhibition and DNA alkylation properties
Wall, M., & Wani, M. (1999). IPC No. U.S. Camptothecin compounds with combined topoisomarase I inhibition and DNA alkylation properties. (Patent No. 5985888).
Abstract
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