.beta.-Alanine esters of camptothecin compounds which areeffective anti-tumor compounds are disclosed. These compoundsinhibit the enzyme topoisomerase I and may alkylate DNA of theassociated topoisomerase I-DNA cleavable complex.
Camptothecin .beta.-alanine esters with topoisomerase I inhibition
Wall, M., Wani, M., Manikumar, G., Balasubramanian, N., & Vyas, D. (2001). IPC No. U.S. Camptothecin .beta.-alanine esters with topoisomerase I inhibition. (Patent No. 6288072).
Abstract
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