• Patent

Camptothecin .beta.-alanine esters with topoisomerase I inhibition

Citation

Wall, M., Wani, M., Manikumar, G., Balasubramanian, N., & Vyas, D. (2001). IPC No. U.S.Camptothecin .beta.-alanine esters with topoisomerase I inhibition (Patent No. 6288072.)

Abstract

.beta.-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.