.beta.-Alanine esters of camptothecin compounds which areeffective anti-tumor compounds are disclosed. These compoundsinhibit the enzyme topoisomerase I and may alkylate DNA of theassociated topoisomerase I-DNA cleavable complex.
Camptothecin .beta.-alanine esters with topoisomerase I inhibition
Wall, M., Wani, M., Manikumar, G., Balasubramanian, N., & Vyas, D. (2001). IPC No. U.S. Camptothecin .beta.-alanine esters with topoisomerase I inhibition. (U.S. Patent No. 6288072). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6288072