• Patent

Camptothecin analogs as potent inhibitors of topoisomerase I

A method for synthesizing camptothecin analogs using a novelhydroxyl-containing tricyclic intermediate and the camptothecinanalogs produced by the process. The camptothecin analogs areeffective inhibitors of topoisomerase.

Citation

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1993). IPC No. U.S.Camptothecin analogs as potent inhibitors of topoisomerase I (Patent No. 5244903.)