A method for synthesizing camptothecin analogs using a novelhydroxyl-containing tricyclic intermediate and the camptothecinanalogs produced by the process. The camptothecin analogs areeffective inhibitors of topoisomerase.
Camptothecin analogs as potent inhibitors of topoisomerase I
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1993). IPC No. U.S. Camptothecin analogs as potent inhibitors of topoisomerase I. (U.S. Patent No. 5244903). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5244903