Camptothecin analogs as potent inhibitors of topoisomerase I
A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase.I and showantileukemic and anti-tumor activity.
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1994). IPC No. U.S.Camptothecin analogs as potent inhibitors of topoisomerase I (Patent No. 5364858.)