• Patent

Camptothecin analogs as potent inhibitors of topoisomerase I

Citation

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1994). IPC No. U.S.Camptothecin analogs as potent inhibitors of topoisomerase I (Patent No. 5364858.)

Abstract

A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase.I and show antileukemic and anti-tumor activity.