A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase.I and showantileukemic and anti-tumor activity.
Camptothecin analogs as potent inhibitors of topoisomerase I
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1994). IPC No. U.S. Camptothecin analogs as potent inhibitors of topoisomerase I. (U.S. Patent No. 5364858). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5364858