Camptothecin analogs having an E-ring ketone
Wall, M., [legal representative] Wall, MA., Wani, M., & Manikumar, G. (2006). Camptothecin analogs having an E-ring ketone. (U.S. Patent No. 7071204). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7071204
Abstract
Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.
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