Camptothecin analogs having an E-ring ketone are effective antitumor compounds. These compounds inhibit the enzyme topoisomerase Iand may alkylate DNA of the associated topoisomerase I DNAcleavable complex.
Camptothecin analogs having an E-ring ketone
Wall, M., [legal representative] Wall, MA., Wani, M., & Manikumar, G. (2006). IPC No. U.S. Camptothecin analogs having an E-ring ketone. (U.S. Patent No. 7071204).
Abstract
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