Camptothecin analogs having an E-ring ketone
Camptothecin analogs having an E-ring ketone are effective antitumor compounds. These compounds inhibit the enzyme topoisomerase Iand may alkylate DNA of the associated topoisomerase I DNAcleavable complex.
Citation
Wall, M., [legal representative] Wall, M. A., Wani, M., & Manikumar, G. (2006). IPC No. U.S.Camptothecin analogs having an E-ring ketone (Patent No. 7071204.)