• Patent

Camptothecin analogs having an E-ring ketone

Citation

Wall, M., [legal representative] Wall, M. A., Wani, M., & Manikumar, G. (2006). IPC No. U.S.Camptothecin analogs having an E-ring ketone (Patent No. 7071204.)

Abstract

Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.