Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Hernan A. Navarro; Monroe E. Wall; Mansukh C. Wani; Eun-Kyoung Seo; D Lee; YG Shin; HB Chai; Hernan A. Navarro; LB Kardono; I Rahman; GA Cordell; NR Farnsworth; JM Pezzuto; AD Kinghorn; Mansukh C. Wani; Monroe E. Wall

Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Seo, E-K., Lee, D., Shin, YG., Chai, HB., Navarro, H., Kardono, LB., Rahman, I., Cordell, GA., Farnsworth, NR., Pezzuto, JM., Kinghorn, AD., Wani, M., & Wall, M. (2003). Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. Archives of Pharmacal Research, 26(2), 124-127.

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Abstract

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic