Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando
Seo, E-K., Lee, D., Shin, Y. G., Chai, H. B., Navarro, H., Kardono, L. B., ... Wall, M. (2003). Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. Archives of Pharmacal Research, 26(2), 124-127.
Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic