Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer
Phipps, A. I., Newcomb, P. A., Garcia-Albeniz, X., Hutter, C. M., White, E., Fuchs, C. S., ... Chan, A. T. (2012). Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer. Gastroenterology, 143(1), 51–54.e4. DOI: 10.1053/j.gastro.2012.04.052
Genome-wide Association Studies Have Identified 16 Germline Single-nucleotide Polymorphisms (snps) That Are Associated With Colorectal Cancer (crc) Incidence. We Examined The Relationship Between These Snps And Survival Of 2611 Individuals With Crc, Enrolled In 5 Cohort Studies. We Used Cox Regression Analysis To Associate Snps With Overall And Crc-specific Survival Times. The Minor Allele In Rs4939827 (smad7) was associated with reduced overall survival (hazard ratio, 1.16; 95% confidence interval, 1.06-1.27; P = .002) and disease-specific survival (hazard ratio, 1.17; 95% confidence interval, 1.05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC.