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Antimicrobial activity of simplified mimics of celogentin C
Thombare, V. J., Holden, J. A., Pal, S., Reynolds, E. C., Chattopadhyay, A., O'Brien-Simpson, N. M., & Hutton, C. A. (2018). Antimicrobial activity of simplified mimics of celogentin C. Tetrahedron, 74(12), 1288-1293. https://doi.org/10.1016/j.tet.2017.12.032
Linear and bicyclic analogues of the peptide natural product, celogentin C, have been prepared in which the sidechain-sidechain crosslinks in celogentin are omitted or replaced with a mesitylenyl moiety. The simplified bicyclic peptides display moderate antibacterial activity, potentially through inhibition of bacterial protomicrotubule formation, while the linear analogs show higher antibacterial activity through a possible membrane disruption mechanism. (C) 2017 Elsevier Ltd. All rights reserved.
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