Amide Isosteres of Oroidin
Richards, J. J., Reyes, S., Stowe, S. D., Tucker, A. T., Ballard, T. E., Mathies, L. D., ... Melander, C. (2009). Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity. Journal of Medicinal Chemistry, 52(15), 4582-4585. DOI: 10.1021/jm900378s
The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues arc described. The most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans in comparison to other similar isosteric analogues and the natural product oroidin.