• Patent

Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer

Citation

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1995). IPC No. U.S.Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer (Patent No. 5401747.)

Abstract

A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase. I and show antileukemic and anti-tumor activity.