• Patent

Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer

A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase. I and showantileukemic and anti-tumor activity.

Citation

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1995). IPC No. U.S.Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer (Patent No. 5401747.)