RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
α-synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease
Gatto, N. M., Rhodes, S. L., Manthripragada, A. D., Bronstein, J., Cockburn, M., Farrer, M., & Ritz, B. (2010). α-synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease. Neuroepidemiology, 35(3), 191-195. https://doi.org/10.1159/000315157
Background: Although of great interest and suggested in prior reports, possible alpha-synuclein (SNCA) gene-environment interactions have not been well investigated in humans. Methods: We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of SNCA variations and two important environmental factors, pesticide exposures and smoking. Results/Conclusions: Similar to recent meta-and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the SNCA REP1 259 genotype, and a higher risk in subjects who were either homozygous or heterozygous for the REP1 263 genotype, especially among subjects with an age of onset
RTI shares its evidence-based research - through peer-reviewed publications and media - to ensure that it is accessible for others to build on, in line with our mission and scientific standards.