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7-substituted camptothecin and camptothecin analogs and methods for producing the same

Wani, M., Manikumar, G., Wall, M., & [legal representative] Wall, MA. (2006). 7-substituted camptothecin and camptothecin analogs and methods for producing the same. (U.S. Patent No. 7067666). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7067666

Abstract

Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.

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