Methods of forming camptothecin compounds which are effectiveanti-tumor compounds are disclosed. These compounds inhibit theenzyme topoisomerase I and may alkylate DNA of the associatedtopoisomerase I-DNA cleavable complex.
7-substituted camptothecin and camptothecin analogs and methods for producing the same
Wani, M., Manikumar, G., Wall, M., & [legal representative] Wall, MA. (2006). IPC No. U.S. 7-substituted camptothecin and camptothecin analogs and methods for producing the same. (U.S. Patent No. 7067666).
Abstract
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