• Patent

7-substituted camptothecin and camptothecin analogs and methods for producing the same

Citation

Wani, M., Manikumar, G., Wall, M., & [legal representative] Wall, M. A. (2006). IPC No. U.S.7-substituted camptothecin and camptothecin analogs and methods for producing the same (Patent No. 7067666.)

Abstract

Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.