• Journal Article

3 beta-phenyl-2 beta-substituted tropanes - An SAR analysis

Citation

Carroll, F., Lewin, A., & Kuhar, M. J. (1998). 3 beta-phenyl-2 beta-substituted tropanes - An SAR analysis. Medicinal Chemistry Research, 8(1-2), 59-65.

Abstract

The 2 beta-carbomethoxy group in cocaine and WIN 35,065-2 can be replaced by a number of other groups with little or no loss in binding affinity to the DAT. Structure-activity relationship (SAR) studies of some 3 beta-aryl-2 beta-substituted tropanes are reviewed in this article.