17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
Cook, C., Kepler, J., Shetty, R. S., Bartley, G. S., & Lee, D. Y. (1999). IPC No. U.S.17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties (Patent No. 5962444.)
The invention is directed to17.beta.-nitro-11.beta.-arylsteroids of formula I: ##STR1## whereinR.sup.1, R.sup.6, R.sup.7, R.sup.12 and X are as defined by thespecification. The compounds exhibit potent antiprogestationalactivity and are useful in the treatment of fibroids,endometriosis, cervical ripening prior to delivery, hormonereplacement therapy and in the control of fertility.