A 11.beta.-aryl-19-norprogesterone steroid of the formula:##STR1## wherein (i) R.sup.1 is H, C.sub.1-4 alkyl, C.sub.2-4alkenyl, C.sub.2-4 alkynyl, OH, OC(O)CH.sub.3, or OC(O)R.sup.5 ,wherein R.sup.5 is C.sub.2-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8alkynyl or aryl, R.sub.2 is H, R.sup.3 is H, C.sub.1-4 alkyl,C.sub.2-4 alkenyl or C.sub.2-4 alkynyl, R.sup.4 is H, CH.sub.3, For Cl, R.sup.6 is H, (CH.sub.3).sub.2 N, CH.sub.3 O, CH.sub.3 CO,CH.sub.3 S, CH.sub.3 SO, CH.sub.3 SO.sub.2, and X is O orNOCH.sub.3 ; or (ii) R.sup.1 and R.sup.2 taken together are acarbon-carbon bond and R.sup.3, R.sup.4, R.sup.6 and X are asdefined above; or (iii) R.sup.1 and R.sup.3 taken together are--CH.sub.2 -- or --N.dbd.N--CH.sub.2 --, R.sup.2 is H and R.sup.4,R.sup.6 and X are as defined above; or (iv) R.sup.2 and R.sup.3taken together are .dbd.CH.sub.2 and R.sup.1 , R.sup.4, R.sup.6 andX are as defined above.
11 .beta.-substituted progesterone analogs
Cook, C., Wani, M., Lee, YW., Reel, JR., & Rector, D. (1991). IPC No. U.S. 11 .beta.-substituted progesterone analogs. (Patent No. 5073548).