• Patent

10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition

Citation

Wall, M., Wani, M., Manikumar, G., Balasubramanian, N., & Vyas, D. (2001). IPC No. U.S.10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition (Patent No. 6268375.)

Abstract

Camptothecin compounds having a C.sub.10 11 O--(CF.sub.2).sub.n O group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.