Scott Runyon

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Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis

Arylpiperazine Opioid Receptor Antagonists

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dim ethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profi

Discovery of novel proline-based neuropeptide FF receptor antagonists

GPCR activation: Principle component analysis as a diagnostic signature correlated with SAR

Potent and selective tetrahydroisoquinoline kappa opioid receptor antagonists of lead compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic)

Formulation and characterization of conjugate vaccines to reduce opioid use disorders suitable for pharmaceutical manufacturing and clinical evaluation

Discovery of a novel small molecule agonist scaffold for the APJ receptor

Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

Indenopyride Derivative RTI-4587-073(1): A Candidate for Male Contraception in Stallions

Acute and chronic effects of a contraceptive compound RTI-4587-073(l) on testicular histology and endocrine function in miniature horse stallions

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3-and 4-methyl substituents

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor

Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product

Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl ]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity

Development of novel neuroactive steroids for the potential treatment of Neurological Disorders

Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists

2018 College on Problems of Drug Dependence Annual Meeting

Discovery of 1,3-disubstituted pyrazole peripheral cannabinoid receptor partial agonists

Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats