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Showing results 1 to 20 of 60.
Article
Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models
April 17, 2024
Article
Design, synthesis, and structure–activity relationship studies of novel GPR88 agonists (4-substituted-phenyl)acetamides based on the reversed amide scaffold
December 12, 2023
Article
The development of diphenyleneiodonium analogs as GPR3 agonists
October 01, 2023
Article
Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects
December 05, 2022
Article
Structure-activity relationship development efforts towards peripherally selective analogs of the cannabinoid receptor partial agonist BAY 59-3074
September 02, 2022
Article
Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids
July 01, 2021
Article
Discovery of arylsulfonamides as dual orexin receptor agonists
June 24, 2021
Article
Therapeutic and prophylactic vaccines to counteract fentanyl use disorders and toxicity
December 10, 2020
Article
Blocking alcoholic steatosis in mice with a peripherally restricted purine antagonist of the type 1 cannabinoid receptor
May 24, 2018
Article
Re-sensitizing multidrug resistant bacteria to antibiotics by targeting bacterial response regulators: Characterization and comparison of interactions between 2-aminoimidazoles and the response regulators bfmr fromand qseb fromspp
February 13, 2018
Article
Discovery of novel proline-based neuropeptide FF receptor antagonists
October 18, 2017
Article
Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis
October 01, 2017
Article
GPCR activation: Principle component analysis as a diagnostic signature correlated with SAR
April 02, 2017
Article
Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity?
February 15, 2017
Article
Effect of substitution on the aniline moiety of the GPR88 agonist 2-PCCA: Synthesis, structure-activity relationships, and molecular modeling studies
October 19, 2016
Article
Regulation of the apelinergic system and its potential in cardiovascular disease: Peptides and small molecules as tools for discovery
October 22, 2015
Article
The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor
September 01, 2015
Article
Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor
April 01, 2015
Article
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2
January 15, 2015
Article
Identifying structural determinants of potency for analogs of apelin-13: Integration of C-terminal truncation with structure-activity
June 01, 2014