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Search Results

Showing results 1 to 20 of 60.

Article

Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

April 17, 2024
Article

Design, synthesis, and structure–activity relationship studies of novel GPR88 agonists (4-substituted-phenyl)acetamides based on the reversed amide scaffold

December 12, 2023
Article

The development of diphenyleneiodonium analogs as GPR3 agonists

October 01, 2023
Article

Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects

December 05, 2022
Article

Structure-activity relationship development efforts towards peripherally selective analogs of the cannabinoid receptor partial agonist BAY 59-3074

September 02, 2022
Article

Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids

July 01, 2021
Article

Discovery of arylsulfonamides as dual orexin receptor agonists

June 24, 2021
Article

Therapeutic and prophylactic vaccines to counteract fentanyl use disorders and toxicity

December 10, 2020
Article

Blocking alcoholic steatosis in mice with a peripherally restricted purine antagonist of the type 1 cannabinoid receptor

May 24, 2018
Article

Re-sensitizing multidrug resistant bacteria to antibiotics by targeting bacterial response regulators: Characterization and comparison of interactions between 2-aminoimidazoles and the response regulators bfmr fromand qseb fromspp

February 13, 2018
Article

Discovery of novel proline-based neuropeptide FF receptor antagonists

October 18, 2017
Article

Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis

October 01, 2017
Article

GPCR activation: Principle component analysis as a diagnostic signature correlated with SAR

April 02, 2017
Article

Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity?

February 15, 2017
Article

Effect of substitution on the aniline moiety of the GPR88 agonist 2-PCCA: Synthesis, structure-activity relationships, and molecular modeling studies

October 19, 2016
Article

Regulation of the apelinergic system and its potential in cardiovascular disease: Peptides and small molecules as tools for discovery

October 22, 2015
Article

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor

September 01, 2015
Article

Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor

April 01, 2015
Article

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

January 15, 2015
Article

Identifying structural determinants of potency for analogs of apelin-13: Integration of C-terminal truncation with structure-activity

June 01, 2014