Brian F. Thomas

Expertise

Pharmacology
Medicinal Chemistry
Analytical Chemistry
Mass Spectrometry

Biography

Brian F. Thomas, PhD, is currently the director of Analytical Chemistry and Pharmaceutics at RTI. He has nearly 20 years of experience in analytical chemistry and mass spectrometry (MS). He is the principal investigator/co-principal investigator on two National Institute on Drug Abuse repository and purity specification contracts. He also holds an R01 grant with the National Institutes of Health. His principal duties include overseeing the development of chromatographic assays (gas chromatography [GC], high-performance liquid chromatography [HPLC], GC/MS, HPLC/MS) and spectrophotometric assays for the qualitative and quantitative analysis of bulk chemicals or chemicals in dosage formulations, biological fluids, tissues, or other complex matrices. Dr. Thomas was recently awarded RTI’s President’s Award for his scientific contributions to the institute.

Education

PhD, Pharmacology, Virginia Commonwealth University; BA, Biology, Kenyon College.

Selected Publications

Paine, M.F., Widmer, W.W., Hart, H.L., Pusek, S.N., Beavers, K.L., Criss, A.B., Brown, S.S., Thomas, B.F., & Watkins, P.B. (May 2006). A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction. American Journal of Clinical Nutrition, 83 (5):1097-1105.

Beardsley, P.M., & Thomas, B.F. (2005 Sep). Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders. Behavioural Pharmacology, 16 (5-6):275-296.

Thomas, B.F., Francisco, M.E.Y., Seltzman, H.H., Thomas, J.B., Fix, S.E., Schulz, A.K., Gilliam, A.F., Pertwee, R.G., & Stevenson, L.A. (2005). Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-py razole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities. Bioorganic and Medicinal Chemistry, 13 (18):5463-5474.

Fischer, L., Mahoney, C., Jeffcoat, A.R., Koch, M.A., Thomas, B.F., Valentine, J.L., Stinchcombe, T., Boan, J., Crowell, J.A., & Zeisel, S.H. (2004). Clinical Characteristics and Pharmacokinetics of Purified Soy Isoflavones: Multiple-Dose Administration to Men with Prostate Neoplasia. Nutrition and Cancer, 48 (2):160-170.

Hunt, P.A., Koehler, K.E., Susiarjo, M., Hodges, C.A., Ilagan, A., Voigt, R.C., Thomas, S., Thomas, B.F., & Hassold, T.J. (2003). Bisphenol a exposure causes meiotic aneuploidy in the female mouse. Current Biology, 13 (7):546-553.

Bloedon, L.T., Jeffcoat, A.R., Lopaczynski, W., Schell, M.J., Black, T.M., Dix, K.J., Thomas, B.F., Albright, C., Busby, M.G., Crowell, J.A., & Zeisel, S.H. (2002). Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women. American Journal of Clinical Nutrition, 76 (5):1126-1137.

Keimowitz, A.R., Martin, B.R., Razdan, R.K., Crocker, P.J., Mascarella, S.W., & Thomas, B.F. (2000). QSAR analysis of Delta(8)-THC analogues: Relationship of side- chain conformation to cannabinoid receptor affinity and pharmacological potency. Journal of Medicinal Chemistry, 43 (1):59-70.

Thomas, B.F., Burgess, J.P., Coleman, D.P., Scheffler, N.M., Jeffcoat, A.R., & Dix, K.J. (1999). Isolation and identification of novel metabolites of gemfibrozil in rat urine. Drug Metabolism and Disposition, 27 (1):147-157.

Martin, B.R., Thomas, B.F., & Razdan, R.K. (1995). Structural requirements for cannabinoid receptor probes. In R. Pertwee (Ed.), Cannabinoid Receptors (Neuroscience Perspectives). San Diego, CA: Academic Press.

Thomas, B.F., Wei, X., & Martin, B.R. (1992). Characterization and Autoradiographic Localization of the Cannabinoid Binding Site in Rat Brain Using [3H]11-OH-D9-THC-DMH1. Journal of Pharmacology and Experimental Therapeutics, 263 (3):1383.

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