Analytical chemistry for assessing medication adherence, 1st edition

By S Tanna, G Lawson, Brian Thomas

The lack of adherence to medication is a growing public health problem worldwide and is costing many patients their good health and healthcare systems billions of dollars. Analytical Chemistry for Assessing Medication Adherence introduces the concept of medication adherence/compliance and reports international perspectives on medication adherence while highlighting its importance. It then describes the opportunities for analytical chemistry to assess medication adherence and thereby provide an evidence base for clinicians to improve patient health outcomes. The authors highlight the strengths and weaknesses of each of the analytical techniques cited in addition to categorizing the findings in terms of the biological samples used to assess adherence and identifying methods to extract biological samples prior to analysis. The final chapter provides the authors’ perspective in this area, emphasizing the importance of medication optimization for individual patients. Published by Elsevier in partnership with RTI Press, Analytical Chemistry for Assessing Medication Adherence is the second volume in the Emerging Issues in Analytical Chemistry series, which is edited by RTI’s Brian F. Thomas.


Tanna, S., Lawson, G., & Thomas, B. (Ed.) (2016). Analytical chemistry for assessing medication adherence, 1st edition. (RTI Press Publication No. BK-Elsevier-02), (Emerging Issues in Analytical Chemistry; Vol. 2). Cambridge, MA: Elsevier in cooperation with RTI Press.


S TannaSangeeta Tanna has a PhD in Pharmaceutics and is a Reader in Pharmaceutical Bioanalysis. Her expertise and research interests are the pharmaceutical bioanalysis and drug delivery fields. Her early research focused on developing instrumental methods for measuring the glucose-dependent delivery of insulin from a “smart” gel. This led to the development of microanalytical methodologies for the determination of therapeutic drugs from dried blood spots based on LC-MS, LC-MS/MS, and LC-HRMS studies. Applications of this work to patient healthcare include improved medications for newborn babies and to assess adherence to cardiovascular drug therapy for adult patients. She has a track record of published papers, invited international conference presentations, grants, and awards for this research.

G LawsonGraham Lawson has a PhD in Analytical Chemistry and his expertise is in instrumental analysis, in disparate areas such as environmental exposure in the polymer industry, the identification of migrants from food packaging, and factors influencing drug delivery and clinical applications. The unifying themes are the detection of ultra-low levels of contamination in complex matrices and the protection of people from adverse exposures. Dr. Lawson’s current research interests include novel analytical techniques applied to dried blood spot analyses and to counterfeit drug detection.

Brian ThomasBrian F. Thomas, PhD, is Principal Scientist, Analytical Chemistry and Pharmaceutics, at RTI International. He has more than 20 years of experience in analytical chemistry and mass spectrometry. He is the principal investigator/co-principal investigator on two National Institute on Drug Abuse repository and purity specification contracts. His principal duties include overseeing the development of chromatographic assays and spectrophotometric assays for the qualitative and quantitative analysis of bulk chemicals or chemicals in dosage formulations, biological fluids, tissues, or other complex matrices. Dr. Thomas was recently awarded RTI’s President’s Award for his scientific contributions to the institute.

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