Analytical assessment of e-cigarettes From contents to chemical and particle exposure profiles (1st ed.)

By Konstantinos Farsalinos, Gene Gillman, Stephen Hecht, Riccardo Polosa, Jonathan Thornburg, Brian Thomas

A volume in the Emerging Issues in Analytical Chemistry series, Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles addresses the many issues surrounding electronic cigarettes in an unprecedented level of scientific detail. The plethora of product devices, formulations, and flavors, combined with the lack of industry standards and labeling requirements, quality control, and limited product oversight, has given rise to public concern about initiation of use and potential for adverse exposure and negative long-term health outcomes. This volume discusses how analytical methods can address these issues and support the manufacturing, labeling, distribution, testing, regulation, and monitoring for consistency of products with known chemical content and demonstrated performance characteristics.

The book begins with the background on aerosol drug delivery services and e-cigarettes, constituents of nicotine-containing liquid dosing formulations, typical use scenarios and associated aerosol emissions, and chemical exposures and pharmacological and toxicological effect profiles, and then continues with descriptions of the analytical methods used to characterize the chemicals in formulations and emissions from e-cigarettes, including their stability, physical particle-size distribution and thermal degradation under commonly employed conditions of use.

Analytical methods enabling detection of biomarkers of exposure and harm in complex biological matrices are discussed, with an emphasis on constituents or emissions of current medicinal interest or with the potential to produce harm. Opportunities and challenges for analytical chemistry in supporting the continued development and use of safe and consistent dosage formulations as alternatives to tobacco products are also explored, with a concluding section describing an analytical approach to a risk-benefit assessment of e-cigarette use on human health.

Published by Elsevier in partnership with RTI Press, Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles is the fifth in the Emerging Issues in Analytical Chemistry series, which is edited by RTI’s Brian F. Thomas.


Farsalinos, K., Gillman, G., Hecht, S., Polosa, R., Thornburg, J., & Thomas, B. (Ed.) (2016). Analytical assessment of e-cigarettes: From contents to chemical and particle exposure profiles (1st ed.). (RTI Press Publication No. BK-Elsevier-05), (Emerging Issues in Analytical Chemistry series; Vol. 5). Cambridge, MA: Elsevier in cooperation with RTI Press.


Konstantinos Farsalinos

Gene Gillman

Stephen Hecht

Riccardo Polosa

Jonathan Thornburg

Brian ThomasBrian F. Thomas, PhD, is Principal Scientist, Analytical Chemistry and Pharmaceutics, at RTI International. He has more than 20 years of experience in analytical chemistry and mass spectrometry. He is the principal investigator/co-principal investigator on two National Institute on Drug Abuse repository and purity specification contracts. His principal duties include overseeing the development of chromatographic assays and spectrophotometric assays for the qualitative and quantitative analysis of bulk chemicals or chemicals in dosage formulations, biological fluids, tissues, or other complex matrices. Dr. Thomas was recently awarded RTI’s President’s Award for his scientific contributions to the institute.

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