Camptothecin and analogs thereof and pharmaceutical compositions and method using them
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1992). Camptothecin and analogs thereof and pharmaceutical compositions and method using them. (U.S. Patent No. 5122526). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5122526
Abstract
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anit-tumor activity.
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