10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
Wall, M., Wani, M., Manikumar, G., Balasubramanian, N., & Vyas, D. (2001). 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition. (U.S. Patent No. 6268375). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6268375
Abstract
Camptothecin compounds having a C.sub.10 11 O--(CF.sub.2).sub.n O group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
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