Synthesis of camptothecin and analogs thereof
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1990). Synthesis of camptothecin and analogs thereof. (U.S. Patent No. 4894456). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=4894456
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.