The effects of a lipid-based nutrient supplement and antiretroviral therapy in a randomized controlled trial on iron, copper, and zinc in milk from HIV-infected Malawian mothers and associations with maternal and infant biomarkers
Hampel, D., Shahab-ferdows, S., Gertz, E., Flax, V. L., Adair, L. S., Bentley, M. E., Jamieson, D. J., Tegha, G., Chasela, C. S., Kamwendo, D., Van Der Horst, C. M., & Allen, L. H. (2017). The effects of a lipid-based nutrient supplement and antiretroviral therapy in a randomized controlled trial on iron, copper, and zinc in milk from HIV-infected Malawian mothers and associations with maternal and infant biomarkers. Maternal & Child Nutrition, 14, e12503. Article 12503. Advance online publication. https://doi.org/10.1111/mcn.12503
We evaluated effects of antiretroviral (ARV) therapy and lipid-based nutrient supplements (LNSs) on iron, copper, and zinc in milk of exclusively breastfeeding HIV-infected Malawian mothers and their correlations with maternal and infant biomarkers. Human milk and blood at 2, 6, and 24weeks post-partum and blood during pregnancy (30weeks gestation) were collected from 535 mothers/infant-pairs in the Breastfeeding, Antiretrovirals, and Nutrition study. The participants received ARV, LNS, ARV and LNS, or no intervention from 0 to 28weeks post-partum. ARVs negatively affected copper and zinc milk concentrations, but only at 2weeks, whereas LNS had no effect. Among all treatment groups, approximately 80-90% of copper and zinc and
