• Journal Article

Synthesis of morphine-3,6-di-beta-D-glucuronide

Citation

Berrang, B., Brine, G., & Carroll, F. (1997). Synthesis of morphine-3,6-di-beta-D-glucuronide. Synthesis, 1997(10), 1165-1168. DOI: 10.1055/s-1997-3187

Abstract

The synthesis of morphine-3,6-di-beta-D-glucuronide as the monolithium salt from a fully protected morphine-6-beta-D-glucuronide 12 via selective 3-deacetylation followed by Lewis acid-catalyzed 3-glucuronidation, and stepwise deprotection with lithium hydroxide is described.