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Synthesis of morphine-3,6-di-beta-D-glucuronide

The synthesis of morphine-3,6-di-beta-D-glucuronide as the monolithium salt from a fully protected morphine-6-beta-D-glucuronide 12 via selective 3-deacetylation followed by Lewis acid-catalyzed 3-glucuronidation, and stepwise deprotection with lithium hydroxide is described.


Berrang, B., Brine, G., & Carroll, F. (1997). Synthesis of morphine-3,6-di-beta-D-glucuronide. Synthesis, 1997(10), 1165-1168. https://doi.org/10.1055/s-1997-3187

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