• Journal Article

Synthesis and pharmacology of 1-methoxy analogs of CP-47,497

Citation

Huffman, J. W., Hepburn, S. A., Reggio, P. H., Hurst, D. P., Wiley, J., & Martin, B. R. (2010). Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorganic and Medicinal Chemistry, 18(15), 5475-5482.

Abstract

Three 1-methoxy analogs of CP-47,497 (7, 8, and 19) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although these compounds exhibit selectivity for the CB(2) receptor none have significant affinity for either receptor. Modeling and receptor docking studies were carried out, which provide a rationalization for the weak affinities of these compounds for either receptor. (C) 2010 Elsevier Ltd. All rights reserved