• Article

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol

Biosynthesis Inhibition: O-5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2-arachidonoylglycerol, was synthesized and found to be potent (IC50=100?nm) and selective versus other proteins and enzymes of the endocannabinoid system in?vitro and active in?vivo at reducing food intake in mice.

Citation

Bisogno, T., Burston, JJ., Rai, R., Allara, M., Saha, B., Mahadevan, A., ... Di Marzo, V. (2009). Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol. ChemMedChem, 4(6), 946-950. DOI: 10.1002/cmdc.200800442

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