• Journal Article

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol

Citation

Bisogno, T., Burston, J. J., Rai, R., Allara, M., Saha, B., Mahadevan, A., ... Di Marzo, V. (2009). Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol. ChemMedChem, 4(6), 946-950. DOI: 10.1002/cmdc.200800442

Abstract

Biosynthesis Inhibition: O-5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2-arachidonoylglycerol, was synthesized and found to be potent (IC50=100?nm) and selective versus other proteins and enzymes of the endocannabinoid system in?vitro and active in?vivo at reducing food intake in mice.