• Journal Article

Synthesis of 3 beta-(4-[I-125]Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ([I-125]RTI-229)

Citation

Zhong, D., Kotian, P., Wyrick, C., Seltzman, H., Kepler, J., Boja, J. W., ... Carroll, F. (1999). Synthesis of 3 beta-(4-[I-125]Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ([I-125]RTI-229). Journal of Labelled Compounds and Radiopharmaceuticals, 42(3), 281-286.

Abstract

A WIN 35,055-2 analog, 3 beta-(4-iodophenyl)tropane-2 beta-pyrrolidine carboxamide (RTI-229), has been radiolabelled with iodine-125 by radioiododestannylation of the corresponding trimethyltin derivative using carrier-free sodium iodide-125 as the isotope source. Purification by reversed-phase HPLC gives [I-125]RTI-229 in good yield (89.4%) with high radiochemical purity (>99%) and high specific activity (2125 mCi/mu mol, 78.6 GBq/mu mol, based on the specific activity of the (NaI)-I-125 used)