Cytochrome P450s are a class of heme proteins involved in the metabolism of a wide variety of xenobiotic substances in many species in nature. In mammalian species, these enzymes are found in a number of organs, most notably the liver, and are the enzymes primarily responsible for the transformation of a number of exogenous compounds into products which are soluble, benign forms and may be excreted. The products of such P450 metabolism, however, can be toxic or even carcinogenic and hence the importance of fundamental studies of determinants of both enzymatic efficacy and product specificity.
The structure and electronic properties of oxy intermediates in the enzymatic cycle of cytochrome P450s
Harris, D. (2000). The structure and electronic properties of oxy intermediates in the enzymatic cycle of cytochrome P450s. In CJ. Rhodes (Ed.), Toxicology of the Human Environment: The Critical Role of Free Radicals (pp. 397-420). Taylor & Francis Ltd.
Abstract
Publications Info
To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.
Meet the Experts
View All ExpertsRecent Publications
Article
What's in a name? A data-driven method to identify optimal psychotherapy classifications to advance treatment research on co-occurring PTSD and substance use disorders
Article
Grandi Byen-supporting child growth and development through integrated, responsive parenting, nutrition and hygiene
Article
Effects of additional context information in prescription drug information sheets on comprehension and risk and efficacy perceptions
Article