STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children
To the Editor:<br>Food allergy, affecting up to 8% of children in the United States,1 is most often mediated by allergen-specific IgE antibodies in the blood. Food allergen sensitization is an intermediate phenotype measured by specific IgE blood tests or skin prick tests (SPTs) and used in the diagnosis of food allergy. Despite family history being a risk factor, no genetic variants have been conclusively identified for food sensitization or clinical food allergy.2 By using the Mexico City Childhood Asthma Study, we examined associations between food sensitization (based on SPTs) and single nucleotide polymorphisms (SNPs) spanning 5 autosomal candidate genes reviewed by Hong et al2 (CD14 [cluster of differentiation 14], IL10, IL13, SPINK5 [serine peptidase inhibitor, Kazal type 5 isoform], and STAT6 [signal transducer and activator of transcription 6]).
Hancock, D., Romieu, I., Chiu, GY., Sienra-Monge, JJ., Li, H., del Rio-Navarro, BE., & London, SJ. (2012). STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children. Journal of Allergy and Clinical Immunology, 129(6), 1673-1676. https://doi.org/10.1016/j.jaci.2012.03.012