• Article

Seizures in Fragile X Syndrome Characteristics and comorbid diagnoses

A national survey of caregivers of individuals with fragile X syndrome addressed characteristics of epilepsy and co-occurring conditions. Of the 1,394 individuals (1,090 males and 304 females) with the full mutation, 14% of males and 6% of females reported seizures. Seizures were more often partial, began between ages 4 and 10 years, and were infrequent and easily treated. Similar characteristics and patterns were seen in medical chart review data from a large clinic cohort of patients with fragile X syndrome. National survey data showed that autism was significantly associated with seizures as a co-occurring condition. Although seizures in fragile X syndrome are typically not severe and easily treated with medications, they appear to be associated with developmentalā€“behavioral comorbidity that impacts function.


Berry-Kravis, E., Raspa, M., Loggin-Hester, L., Bishop, E., Holiday, D., & Bailey, D. (2010). Seizures in Fragile X Syndrome: Characteristics and comorbid diagnoses. American Journal on Intellectual and Developmental Disabilities, 115(6), 461-472. https://doi.org/10.1352/1944-7558-115.6.461