The Relationship between Antidepressant Use and Smoking Cessation in Pregnant Women in Treatment for Substance Abuse
Chisolm, M. S., Brigham, E. P., Tuten, M., Strain, E. C., & Jones, H. (2010). The Relationship between Antidepressant Use and Smoking Cessation in Pregnant Women in Treatment for Substance Abuse. American Journal of Drug and Alcohol Abuse, 36(1), 46-51.
Background: Bupropion's efficacy for smoking cessation in pregnant women is unknown. Objectives: To determine if substance-dependent women prescribed bupropion smoked fewer cigarettes/day than those prescribed citalopram/escitalopram or no antidepressant medication. Methods: Comparison of smoking in bupropion (n = 11), citalopram/escitalopram (n = 17), and no antidepressant (n = 28) groups. Results and Conclusions: Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [-6.4 vs. -.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [-5.3 cigarettes/day]. Scientific Significance: Data support continued study of bupropion in depressed pregnant substance-dependent smokers