• Journal Article

Psychiatric effects of ephedra use: An analysis of food and drug administration reports of adverse events

Citation

Maglione, M., Miotto, K., Iguchi, M., Jungvig, L., Morton, S., & Shekelle, P. G. (2005). Psychiatric effects of ephedra use: An analysis of food and drug administration reports of adverse events. American Journal of Psychiatry, 162(1), 189-191.

Abstract

Objective: As part of a synthesis of evidence regarding the efficacy and safety of ephedra, the authors describe data on Psychiatric adverse events from reports submitted to the Food and Drug Administration (FDA). Method: The authors reviewed all 1,820 adverse event reports related to dietary supplements containing herbal ephedra from FDA MedWatch files as of Sept. 30. 2001. Fifty-seven serious psychiatric events were reported. Results: The most commonly reported events were psychosis. severe depression, mania or agitation, hallucinations, sleep disturbance, and suicidal ideation. Ten events involved physical harm to self or others; five events resulted in legal action due to criminal behavior. Twenty-six events resulted in hospitalization, at least six of which were involuntary Of importance, two-thirds of all cases involved patients with preexisting psychiatric conditions and /or use of other medications or illicit substances. Conclusions: Clinicians should be aware that serious psychiatric symptoms could be associated with ephedra use