• Journal Article

Preparation of a series of 5-methyl-3-(substituted)-[1,2,4]triazines


Gichinga, M., Olson, J., Butala, E., Gilmour, B., Navarro, H., & Carroll, F. (2011). Preparation of a series of 5-methyl-3-(substituted)-[1,2,4]triazines. Tetrahedron Letters, 52(26), 3345-3346. DOI: 10.1016/j.tetlet.2011.04.075


Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5 (mGluR5). Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5.