• Article

Phenobarbital and Temperature Profile During Hypothermia for Hypoxic-Ischemic Encephalopathy

Data from the whole-body hypothermia trial was analyzed to examine the effects of phenobarbital administration prior to cooling (+PB) on the esophageal temperature (T-e) profile, during the induction phase of hypothermia. A total of 98 infants were analyzed. At enrollment, +PB infants had a higher rate of severe hypoxic-ischemic encephalopathy and clinical seizures and lower T-e and cord pH than infants that have not received phenobarbital (-PB). There was a significant effect of phenobarbital itself and an interaction between phenobarbital and time in the T-e profile. Mean T-e in the +PB group was lower than in the -PB group, and the differences decreased over time. In +PB infants, the time to surpass target T-e of 33.5 degrees C and to reach the minimum T-e during overshoot were shorter. In conclusion, the administration of phenobarbital before cooling was associated with changes that may reflect a reduced thermogenic response associated with barbiturates

Citation

Sant'anna, G., Laptook, AR., Shankaran, S., Bara, R., McDonald, S., Higgins, RD., ... Walsh, MC. (2012). Phenobarbital and Temperature Profile During Hypothermia for Hypoxic-Ischemic Encephalopathy. Journal of Child Neurology, 27(4), 451-457. DOI: 10.1177/0883073811419317

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