Pediatric Atorvastatin in Diabetes Trial (PADIT) A pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus

Fifty-one children with type 1 diabetes mellitus (DM1) participated in a double blinded, randomized, cross-over pilot study to determine whether 12 weeks of daily atorvastatin (20 mg daily) would reduce arterial stiffness and improve endothelial function. Secondary analysis demonstrated potential reduction of arterial stiffness following atorvastatin therapy (p = 0.06). Additional long-term prospective studies with larger numbers of patients are needed.

Haller, M. J., Stein, J. M., Shuster, J. J., Theriaque, D., Samyn, M. M., Pepine, C., & Silverstein, J. H. (2009). Pediatric Atorvastatin in Diabetes Trial (PADIT): A pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism, 22(1), 65-68.