• Article

One-step preparation of [2,3-3H]1-aminocyclopropanecarboxylic acid A useful ligand for strychnine-insensitive glycine receptors

Catalytic hydrogenation of 1‐aminocyclopropenecarboxylic acid under tritium gas afforded [2,3‐3H]1‐aminocyclopropanecarboxylic acid with specific activity 26 Ci/mmol, determined by a combination of 1H and 3H NMR. Pilot radioligand binding assays indicate this compound will be a useful probe for the NMDA receptor‐associated strychnine‐insensitive glycine receptor.

Citation

Lewin, A., Lamb, P., Popik, P., & Skolnick, P. (1994). One-step preparation of [2,3-3H]1-aminocyclopropanecarboxylic acid: A useful ligand for strychnine-insensitive glycine receptors. Journal of Labelled Compounds and Radiopharmaceuticals, 34(11), 1063-1068. https://doi.org/10.1002/jlcr.2580341109

DOI Links