• Article

Observed home dampness and mold are associated with sustained spikes in personal exposure to particulate matter less than 10 mu m in diameter in exacerbation-prone children with asthma

Rationale: Home dampness and mold are associated with asthma
severity and exacerbations, but little is known about the nature of
these exposures in at-risk children.
Objectives: To test the hypothesis that observed dampness, water
damage, and mold in the home are associated with higher exposure
to particulate matter less than 10 mm in diameter in a cohort of
at-risk children with asthma.
Methods: We performed a pilot study in 8- to 16-year-old children
with exacerbation-prone asthma (n = 29; Denver Asthma Panel
Study). Exposure to particulate matter less than 10 mm in diameter
was measured over z72 hours with personal wearable monitors
(MicroPEM [RTI International] and iTrack Micro GPS tracker) and
stationary bedroom-located monitors (PEM, MSP Corporation).
Mean percentage personal monitored time was 93% (95% confidence
interval, 90–96%). Mean and spikes of real-time exposure to
particulate matter less than 10 mm in diameter were calculated and, for
personal monitored samples, partitioned into exposure while at home,
school, or other locations. We defined a sustained spike exposure as a
continuous period of 20 minutes or longer during which levels were
greater than 50 mg/mL over the participant’s minimum levels, using
a 2-minute moving average of the particulate matter measurements.
Mold and dampness were assessed by detailed home inspection.
Rationale: Home dampness and mold are associated with asthma
severity and exacerbations, but little is known about the nature of
these exposures in at-risk children.
Objectives: To test the hypothesis that observed dampness, water
damage, and mold in the home are associated with higher exposure
to particulate matter less than 10 mm in diameter in a cohort of
at-risk children with asthma.
Methods: We performed a pilot study in 8- to 16-year-old children
with exacerbation-prone asthma (n = 29; Denver Asthma Panel
Study). Exposure to particulate matter less than 10 mm in diameter
was measured over z72 hours with personal wearable monitors
(MicroPEM [RTI International] and iTrack Micro GPS tracker) and
stationary bedroom-located monitors (PEM, MSP Corporation).
Mean percentage personal monitored time was 93% (95% confidence
interval, 90–96%). Mean and spikes of real-time exposure to
particulate matter less than 10 mm in diameter were calculated and, for
personal monitored samples, partitioned into exposure while at home,
school, or other locations. We defined a sustained spike exposure as a
continuous period of 20 minutes or longer during which levels were
greater than 50 mg/mL over the participant’s minimum levels, using
a 2-minute moving average of the particulate matter measurements.
Mold and dampness were assessed by detailed home inspection.
Rationale: Home dampness and mold are associated with asthma
severity and exacerbations, but little is known about the nature of
these exposures in at-risk children.
Objectives: To test the hypothesis that observed dampness, water
damage, and mold in the home are associated with higher exposure
to particulate matter less than 10 mm in diameter in a cohort of
at-risk children with asthma.
Methods: We performed a pilot study in 8- to 16-year-old children
with exacerbation-prone asthma (n = 29; Denver Asthma Panel
Study). Exposure to particulate matter less than 10 mm in diameter
was measured over z72 hours with personal wearable monitors
(MicroPEM [RTI International] and iTrack Micro GPS tracker) and
stationary bedroom-located monitors (PEM, MSP Corporation).
Mean percentage personal monitored time was 93% (95% confidence
interval, 90–96%). Mean and spikes of real-time exposure to
particulate matter less than 10 mm in diameter were calculated and, for
personal monitored samples, partitioned into exposure while at home,
school, or other locations. We defined a sustained spike exposure as a
continuous period of 20 minutes or longer during which levels were
greater than 50 mg/mL over the participant’s minimum levels, using
a 2-minute moving average of the particulate matter measurements.
Mold and dampness were assessed by detailed home inspection.

Citation

Dutmer, C. M., Schiltz, A. M., Freeman, K. L., Christie, M. J., Cerna, J. A., Cho, S-H., ... Liu, A. H. (2018). Observed home dampness and mold are associated with sustained spikes in personal exposure to particulate matter less than 10 mu m in diameter in exacerbation-prone children with asthma. Annals of the American Thoracic Society, 15(Suppl 2), S131-S132.