• Journal Article

Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales

Citation

Ayers, S., Graf, T. N., Adcock, A., Kroll, D. J., Shen, Q., Swanson, S. M., ... Oberlies, N. H. (2011). Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales. Tetrahedron Letters, 52(40), 5128-5130.

Abstract

A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 mu M, depending on the cell line tested. (C) 2011 Elsevier Ltd. All rights reserved